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Depozytariusz oświadcza, że udziela Uniwersytetowi Łódzkiemu nieodpłatnej licencji niewyłącznej do korzystania z pracy bez ograniczeń czasowych i terytorialnych w zakresie zwielokrotniania utworu i jego rozpowszechniania w formie elektronicznej w Repozytorium Uniwersytetu Łódzkiego oraz poświadcza oryginalność pracy.
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MK-8776 and Olaparib Combination Acts Synergistically in Hepatocellular Carcinoma Cells, Demonstrating Lack of Adverse Effects on Liver Tissues in Ovarian Cancer PDX Model
; ; Marczak, Agnieszka
; ; ; ; ; Bryś, Magdalena ; (MDPI, 2025)
Hepatocellular carcinoma (HCC) cells critically depend on PARP1 and CHK1 activation for survival. Combining the PARP inhibitor (PARPi) olaparib with a CHK1 inhibitor (MK-8776, CHK1i) produced a synergistic effect, reducing ... -
Impact of Short-Term Exposure to Non-Functionalized Polystyrene Nanoparticles on DNA Methylation and Gene Expression in Human Peripheral Blood Mononuclear Cells
(MDPI, 2024-11-28)The aim of the present study was to investigate the concentration- and size-dependent effects of non-functionalized polystyrene nanoparticles (PS-NPs) of varying diameters (29 nm, 44 nm, and 72 nm) on specific epigenetic ... -
Lost in space and time: robust demography and enhanced resilience buffer adverse environmental effects in a highly isolated and sedentary pre-pleistocene landscape vertebrate
(2024-10-11)Background Few animal populations have been studied under the framework of the OCBIL theory, which addresses the ecology and evolution of biodiversity on old climatically buffered infertile landscapes. Available genetic ... -
Polystyrene nanoparticles: the mechanism of their genotoxicity in human peripheral blood mononuclear cells
(Taylor & Francis, 2022)Plastic nanoparticles are widely spread in the biosphere, but health risk associated with their effect on the human organism has not yet been assessed. The purpose of this study was to determine the genotoxic potential ... -
Skin Microbiome in Prurigo Nodularis
; ; ; ; ; ; Strapagiel, Dominik; (MDPI, 2023)
Prurigo nodularis (PN) is a chronic condition characterized by the presence of nodular lesions accompanied by intense pruritus. The disease has been linked to several infectious factors, but data on the direct presence ... -
The Evolution of Diagnostic Techniques in the Paleopathology of Tuberculosis: A Scoping Review
(Case Western Reserve University, 2023)Tuberculosis (TB) is an ancient chronic infectious disease that remains a global health concern. In human remains, the most common and characteristic clinical signs are the skeletal modifications involving the spine, such ... -
rs67047829 genotypes of ERV3-1/ZNF117 are associated with lower body mass index in the Polish population
; ; ; ; ; ; ; Strapagiel, Dominik (Springer Nature, 2023)
There is now substantial evidence that zinc-finger proteins are implicated in adiposity. Aims were to datamine for high-frequency (near-neutral selection) pretermination-codon (PTC) single-nucleotide polymorphisms (SNPs; ... -
Evolutionary trade-of between innate and acquired immune defences in birds
(BMC Part of Springer Nature, 2023)Background The development, maintenance, and use of immune defences are costly. Therefore, animals face tradeofs in terms of resource allocation within their immune system and between their immune system and other ... -
Special issue on “Anatomical radiology and morphological studies applied to radiological and palaeoradiological contexts”
(Firenze University Press, 2023) -
Introduction of a multiplex amplicon sequencing assay to quantify DNA methylation in target cytosine markers underlying four selected epigenetic clocks
; ; ; ; ; ; ; ; ; Pruszkowska-Przybylska, Paulina; ; ; ; ; ; ; ; ; ; (Springer Nature, 2023)
Background: DNA methylation analysis has proven to be a powerful tool for age assessment. However, the implementation of epigenetic age prediction in diagnostics or routine forensic casework requires appropriate laboratory ... -
Discover the anatomy of the mummies: how imaging techniques contribute to understanding disease in the past
; ; Galassi, Francesco Maria; (Firenze University Press, 2023)
Mummies are the well-preserved remains of humans or animals in which non-bony tissue has been maintained naturally or artificially. Their significance lies in their contribution to paleopathological research, which involves ... -
Indoxyl sulfate induces apoptosis in mononuclear blood cells via mitochondrial pathway
(Springer Nature, 2023)The consequence of chronic kidney disease is the accumulation of metabolic products called uremic toxins in the body. Indoxyl sulfate (IS) is a toxin with a high affinity for proteins. This study focuses on the deleterious ... -
The artificial oxygen carrier erythrocruorin—characteristics and potential significance in medicine
(Springer Nature, 2023)The diminishing supply and increasing costs of donated blood have motivated research into novel hemoglobin-based oxygen carriers (HBOCs) that can serve as red blood cell (RBC) substitutes. HBOCs are versatile agents that ... -
Digit ratio (2D:4D), laryngeal cancer and vocal fold leukoplakia
(Springer Nature, 2023)Background - To date, there are no studies that have analyzed the possible influence of exposure to prenatal sex hormones on the risk of laryngeal cancer (LC) and premalignant laryngeal lesion—vocal fold leukoplakia (VFL). ... -
The Tobacco Smoke Component, Acrolein, as a Major Culprit in Lung Diseases and Respiratory Cancers: Molecular Mechanisms of Acrolein Cytotoxic Activity
(MDPI, 2023)Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant that seriously threatens human health and life. Due to its high reactivity, cytotoxicity and genotoxicity, acrolein is involved in ... -
Loss of fungal symbionts and changes in pollinator availability caused by climate change will affect the distribution and survival chances of myco-heterotrophic orchid species
(Springer Nature, 2023)The first comprehensive species distribution models for orchid, its fungal symbionts and pollinator are presented. To evaluate impact of global warming on these organisms three different projections and four various climate ... -
MHC Architecture in Amphibians—Ancestral Reconstruction, Gene Rearrangements, and Duplication Patterns
(Oxford University Press, 2023)The hypervariable major histocompatibility complex (MHC) is a crucial component of vertebrate adaptive immunity, but largescale studies on MHC macroevolution in nonmodel vertebrates have long been constrained by methodological ... -
Diet as a Source of Acrolein: Molecular Basis of Aldehyde Biological Activity in Diabetes and Digestive System Diseases
(MDPI, 2023)Acrolein, a highly reactive α,β-unsaturated aldehyde, is a compound involved in the pathogenesis of many diseases, including neurodegenerative diseases, cardiovascular and respiratory diseases, diabetes mellitus, and the ... -
Mycobacterium bovis BCG increase the selected determinants of monocyte/macrophage activity, which were diminished in response to gastric pathogen Helicobacter pylori
; Chyb, Maciej; (Nature Portfolio, 2023)
High antibiotic resistance of gastric pathogen Helicobacter pylori (Hp) and the ability to escape the host immune response prompt searching for therapeutic immunomodulators. Bacillus Calmette–Guerin (BCG) vaccine with ... -
Pegylated Gold Nanoparticles Conjugated with siRNA: Complexes Formation and Cytotoxicity
Okła, Elżbieta; ; ; ; ; ; ; ; (MDPI, 2023)
Drug delivery systems such as dendrimers, liposomes, polymers or gold/silver nanoparticles could be used to advance modern medicine. One significant pharmacological problem is crossing biological barriers by commonly used ...