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Relationship between the Increased Haemostatic Properties of Blood Platelets and Oxidative Stress Level in Multiple Sclerosis Patients with the Secondary Progressive Stage

dc.contributor.authorMorel, Agnieszka
dc.contributor.authorBijak, Michal
dc.contributor.authorMiller, Elżbieta
dc.contributor.authorRywaniak, Joanna
dc.contributor.authorMiller, Sergiusz
dc.contributor.authorSaluk-Bijak, Joanna
dc.date.accessioned2015-06-03T09:22:55Z
dc.date.available2015-06-03T09:22:55Z
dc.date.issued2015-04-01
dc.identifier.issn1942-0994
dc.identifier.urihttp://hdl.handle.net/11089/9280
dc.description.abstractMultiple sclerosis (MS) is the autoimmune disease of the central nervous system with complex pathogenesis, different clinical courses and recurrent neurological relapses and/or progression. Despite various scientific papers that focused on early stage of MS, our study targets selective group of late stage secondary progressive MS patients. The presented work is concerned with the reactivity of blood platelets in primary hemostasis in SP MS patients. 50 SP MS patients and 50 healthy volunteers (never diagnosed with MS or other chronic diseases) were examined to evaluate the biological activity of blood platelets (adhesion, aggregation), especially their response to the most important physiological agonists (thrombin, ADP, and collagen) and the effect of oxidative stress on platelet activity. We found that the blood platelets from SP MS patients were significantly more sensitive to all used agonists in comparison with control group. Moreover, the platelet hemostatic function was advanced in patients suffering from SP MS and positively correlated with increased production of in these cells, as well as with Expanded Disability Status Scale. We postulate that the increased oxidative stress in blood platelets in SP MS may be primarily responsible for the altered haemostatic properties of blood platelets.pl_PL
dc.description.sponsorshipGrants nos. 506/1136 and 545/785 from University of Lodz.pl_PL
dc.language.isoenpl_PL
dc.publisherHindawi; PubMed Centralpl_PL
dc.relation.ispartofseriesOxidative Medicine and Cellular Longevity;Volume 2015
dc.rightsUznanie autorstwa 3.0 Polska*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/pl/*
dc.titleRelationship between the Increased Haemostatic Properties of Blood Platelets and Oxidative Stress Level in Multiple Sclerosis Patients with the Secondary Progressive Stagepl_PL
dc.typeArticlepl_PL
dc.page.number1-10pl_PL
dc.contributor.authorAffiliationMorel Agnieszka, University of Lodz, Department of General Biochemistry, Faculty of Biology and Environmental Protectionpl_PL
dc.contributor.authorAffiliationBijak Michał, University of Lodz, Department of General Biochemistry, Faculty of Biology and Environmental Protectionpl_PL
dc.contributor.authorAffiliationMiller Elżbieta, Medical University of Lodz, Department of Physical Medicinepl_PL
dc.contributor.authorAffiliationRywaniak Joanna, University of Lodz, Department of General Biochemistry, Faculty of Biology and Environmental Protectionpl_PL
dc.contributor.authorAffiliationMiller Sergiusz, Medical University in Lodz, Department of Orthodonticspl_PL
dc.contributor.authorAffiliationSaluk Joanna , University of Lodz, Department of General Biochemistry, Faculty of Biology and Environmental Protectionpl_PL
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