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Molecular Aspects of Senescence and Organismal Ageing—DNA Damage Response, Telomeres, Inflammation and Chromatin

dc.contributor.authorKrupa, Renata
dc.contributor.authorSławińska, Natalia
dc.date.accessioned2021-12-13T12:05:24Z
dc.date.available2021-12-13T12:05:24Z
dc.date.issued2020
dc.identifier.citationSławińska, N.; Krupa, R. Molecular Aspects of Senescence and Organismal Ageing—DNA Damage Response, Telomeres, Inflammation and Chromatin. Int. J. Mol. Sci. 2021, 22, 590. https://doi.org/10.3390/ ijms22020590pl_PL
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/11089/39988
dc.description.abstractCells can become senescent in response to stress. Senescence is a process characterised by a stable proliferative arrest. Sometimes it can be beneficial—for example, it can suppress tumour development or take part in tissue repair. On the other hand, studies show that it is also involved in the ageing process. DNA damage response (DDR) is triggered by DNA damage or telomere shortening during cell division. When left unresolved, it may lead to the activation of senescence. Senescent cells secrete certain proteins in larger quantities. This phenomenon is referred to as senescence-associated secretory phenotype (SASP). SASP can induce senescence in other cells; evidence suggests that overabundance of senescent cells contributes to ageing. SASP proteins include proinflammatory cytokines and metalloproteinases, which degrade the extracellular matrix. Shortening of telomeres is another feature associated with organismal ageing. Older organisms have shorter telomeres. Restoring telomerase activity in mice not only slowed but also partially reversed the symptoms of ageing. Changes in chromatin structure during senescence include heterochromatin formation or decondensation and loss of H1 histones. During organismal ageing, cells can experience heterochromatin loss, DNA demethylation and global histone loss. Cellular and organismal ageing are both complex processes with many aspects that are often related. The purpose of this review is to bring some of these aspects forward and provide details regarding them.pl_PL
dc.language.isoenpl_PL
dc.publisherMDPIpl_PL
dc.relation.ispartofseriesInternational Journal of Molecular Sciences;2
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectageingpl_PL
dc.subjectsenescencepl_PL
dc.subjectDNA damage responsepl_PL
dc.subjecttelomerespl_PL
dc.subjectinflammationpl_PL
dc.subjectchromatinpl_PL
dc.subjectSASPpl_PL
dc.titleMolecular Aspects of Senescence and Organismal Ageing—DNA Damage Response, Telomeres, Inflammation and Chromatinpl_PL
dc.typeArticlepl_PL
dc.page.number16pl_PL
dc.contributor.authorAffiliationLaboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Polandpl_PL
dc.contributor.authorAffiliationLaboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Polandpl_PL
dc.identifier.eissn1422-0067
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dc.contributor.authorEmailrenata.krupa@biol.uni.lodz.plpl_PL
dc.contributor.authorEmailnatalia.slawinska@edu.uni.lodz.plpl_PL
dc.identifier.doi10.3390/ijms22020590
dc.relation.volume22pl_PL
dc.disciplinenauki biologicznepl_PL


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Uznanie autorstwa 4.0 Międzynarodowe
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