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Ruthenium Dendrimers against Human Lymphoblastic Leukemia 1301 Cells

dc.contributor.authorMichlewska, Sylwia
dc.contributor.authorIonov, Maksim
dc.contributor.authorSzwed, Aleksandra
dc.contributor.authorBryszewska, Maria
dc.contributor.authorRogalska, Aneta
dc.contributor.authorSanz del Olmo, Natalia
dc.contributor.authorOrtega, Paula
dc.contributor.authorDenel-Bobrowska, Marta
dc.contributor.authorDe la Mata, F. Javier
dc.contributor.authorJacenik, Damian
dc.contributor.authorShcharbin, Dzmitry
dc.date.accessioned2021-10-22T08:09:54Z
dc.date.available2021-10-22T08:09:54Z
dc.date.issued2020
dc.identifier.citationMichlewska S, Ionov M, Szwed A, Rogalska A, Sanz del Olmo N, Ortega P, Denel M, Jacenik D, Shcharbin D, de la Mata FJ, Bryszewska M. Ruthenium Dendrimers against Human Lymphoblastic Leukemia 1301 Cells. International Journal of Molecular Sciences. 2020; 21(11):4119. https://doi.org/10.3390/ijms21114119pl_PL
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/11089/39510
dc.description.abstractRuthenium atoms located in the surfaces of carbosilane dendrimers markedly increase their anti-tumor properties. Carbosilane dendrimers have been widely studied as carriers of drugs and genes owing to such characteristic features as monodispersity, stability, and multivalence. The presence of ruthenium in the dendrimer structure enhances their successful use in anti-cancer therapy. In this paper, the activity of dendrimers of generation 1 and 2 against 1301 cells was evaluated using Transmission Electron Microscopy, comet assay and Real Time PCR techniques. Additionally, the level of reactive oxygen species (ROS) and changes of mitochondrial potential values were assessed. The results of the present study show that ruthenium dendrimers significantly decrease the viability of leukemia cells (1301) but show low toxicity to non-cancer cells (peripheral blood mononuclear cells—PBMCs). The in vitro test results indicate that the dendrimers injure the 1301 leukemia cells via the apoptosis pathway.pl_PL
dc.description.sponsorshipFunding: This work was co-financed by the Project EUROPARTNER of Polish National Agency for Academic Exchange (NAWA) and Pl-SK 2019–2020 bilateral project -PPN/BIL/2018/1/00150; supported by the project “NanoTENDO” granted by National Science Centre, Poland under the M-ERA.NET 2 of Horizon 2020 programme, project No: 685451. This research was also supported by grants from CTQ2017-86224-P (MINECO), consortiums IMMUNOTHERCAN-CM B2017/BMD-3733, NANODENDMED II-CM ref B2017/BMD-3703 and Project SBPLY/17/180501/000358 Junta de Comunidades de Castilla-La Mancha (JCCM). CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008–2011, IniciativaIngenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. Acknowledgments: N.S.d.O. wishes to thank JCCM for a predoctoral fellowship. This article is based upon work from COST Action CA17140 “Cancer Nanomedicine from the Bench to the Bedside” supported by COST(European Cooperation in Science and Technology).pl_PL
dc.language.isoenpl_PL
dc.publisherMDPIpl_PL
dc.relation.ispartofseriesInternational Journal of Molecular Sciences;21(11)
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject1301 human lymphoblastic leukemiapl_PL
dc.subjectcarbosilane dendrimerpl_PL
dc.subjectrutheniumpl_PL
dc.subjectdrug deliverypl_PL
dc.subjectcytotoxicitypl_PL
dc.titleRuthenium Dendrimers against Human Lymphoblastic Leukemia 1301 Cellspl_PL
dc.typeArticlepl_PL
dc.page.number13pl_PL
dc.contributor.authorAffiliationLaboratory of Microscopic Imaging & Specialized Biological Techniques, Faculty of Biology & Environmental Protection, University of Lodz, 90-237 Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of General Biophysics, Faculty of Biology & Environmental Protection, University of Lodz, 90-236 Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of General Biophysics, Faculty of Biology & Environmental Protection, University of Lodz, 90-236 Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of General Biophysics, Faculty of Biology & Environmental Protection, University of Lodz, 90-236 Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of General Biophysics, Faculty of Biology & Environmental Protection, University of Lodz, 90-236 Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Medical Biophysics, Faculty of Biology & Protection, University of Lodz, 90-236 Lodz, Polandpl_PL
dc.contributor.authorAffiliationNetworking Research Center on Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN), 28029 Madrid, Spainpl_PL
dc.contributor.authorAffiliationNetworking Research Center on Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN), 28029 Madrid, Spainpl_PL
dc.contributor.authorAffiliationDepartment of Organic Chemistry and Inorganic Chemistry, Research Institute of Chemistry “Andrés M. del Rio (IQAR)”, Institute “Ramón y Cajal” for Health Research (IRYCIS), University of Alcalá, 28805 Madrid, Spainpl_PL
dc.contributor.authorAffiliationDepartment of Organic Chemistry and Inorganic Chemistry, Research Institute of Chemistry “Andrés M. del Rio (IQAR)”, Institute “Ramón y Cajal” for Health Research (IRYCIS), University of Alcalá, 28805 Madrid, Spainpl_PL
dc.contributor.authorAffiliationDepartment of Medical Biophysics, Faculty of Biology & Protection, University of Lodz, 90-236 Lodz, Polandpl_PL
dc.contributor.authorAffiliationNetworking Research Center on Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN), 28029 Madrid, Spainpl_PL
dc.contributor.authorAffiliationDepartment of Organic Chemistry and Inorganic Chemistry, Research Institute of Chemistry “Andrés M. del Rio (IQAR)”, Institute “Ramón y Cajal” for Health Research (IRYCIS), University of Alcalá, 28805 Madrid, Spainpl_PL
dc.contributor.authorAffiliationDepartment of Cytobiochemistry, Faculty of Biology & Protection, University of Lodz, 90-236 Lodz, Polandpl_PL
dc.contributor.authorAffiliationInstitute of Biophysics & Cell Engineering of NASB, 220072 Minsk, Belaruspl_PL
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dc.identifier.doi10.3390/ijms21114119
dc.relation.volume4119pl_PL
dc.disciplinenauki biologicznepl_PL
dc.disciplinenauki chemicznepl_PL


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