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Differential Action of Silver Nanoparticles on ABCB1 (MDR1) and ABCC1 (MRP1) Activity in Mammalian Cell Lines

dc.contributor.authorGrzelak, Agnieszka
dc.contributor.authorKrzyżanowski, Damian
dc.contributor.authorKruszewski, Marcin
dc.date.accessioned2021-10-01T10:59:45Z
dc.date.available2021-10-01T10:59:45Z
dc.date.issued2021
dc.identifier.citationKrzyzanowski, D.; Kruszewski, M.; Grzelak, A. Differential Action of Silver Nanoparticles on ABCB1 (MDR1) and ABCC1 (MRP1) Activity in Mammalian Cell Lines. Materials 2021, 14, 3383. https://doi.org/10.3390/ma14123383pl_PL
dc.identifier.urihttp://hdl.handle.net/11089/39305
dc.description.abstractSilver nanoparticles (AgNPs), due to their unique properties have been receiving immense attention in recent years. In addition to their antibacterial and antifungal activities, AgNPs also cause apoptosis, mitochondria disfunction, nucleic acid damage and show potent anticancer properties in both multidrug resistance (MDR) and sensitive tumors. The MDR phenomenon, caused by the presence of ATP-binding cassette (ABC) proteins, is responsible for the failure of chemotherapy. Thus, investigating the influence of widely used AgNPs on ABC transporters is crucial. In the present study, we have examined the cytotoxicity of silver nanoparticles of a nominal size of 20 nm (Ag20) on the cell lines of different tissue origins. In addition, we have checked the ATP-binding cassette transporters’ activity and expression under AgNP exposure. The results indicate that Ag20 shows a toxic effect on tested cells, as well as modulating the expression and transport activity of ABC proteins.pl_PL
dc.language.isoenpl_PL
dc.publisherMDPIpl_PL
dc.relation.ispartofseriesMaterials;14(12), 3383
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectsilver nanoparticlespl_PL
dc.subjectABC transporterspl_PL
dc.subjectATP-binding cassettepl_PL
dc.subjectmultidrug resistancepl_PL
dc.subjectP-glycoproteinpl_PL
dc.titleDifferential Action of Silver Nanoparticles on ABCB1 (MDR1) and ABCC1 (MRP1) Activity in Mammalian Cell Linespl_PL
dc.typeArticlepl_PL
dc.page.number13pl_PL
dc.contributor.authorAffiliationDepartment of Molecular Biophysics, University of Lodz, 90-237 Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Pediatrics, Oncology and Hematology, Medical University of Lodz, 91-738 Lodz, Poland; Laboratory of Epigenetics, Institute of Medical Biology, Polish Academy of Sciences, 93-232 Lodz, Polandpl_PL
dc.contributor.authorAffiliationCentre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, 03-195 Warsaw, Poland; Department of Molecular Biology and Translational Research, Institute of Rural Health, 20-090 Lublin, Polandpl_PL
dc.identifier.eissn1996-1944
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dc.identifier.doi10.3390/ma14123383
dc.disciplinenauki biologicznepl_PL


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