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A brief dive into the phenomenon of cisplatin resistance in non-small-cell lung cancer

dc.contributor.authorSobczak, Maciej
dc.date.accessioned2021-09-30T17:13:07Z
dc.date.available2021-09-30T17:13:07Z
dc.date.issued2021-09-29
dc.identifier.issn1730-2366
dc.identifier.urihttp://hdl.handle.net/11089/39290
dc.description.abstractLung cancer is one of the most lethal types of cancer due to a lack of proper treatment. The rare presence of molecular therapy targets forces the use of platinum-based drugs. Cisplatin, approved by the USA as an anticancer therapy in the 1970s, is still one of the most prominent therapies against lung cancer. Unfortunately, the biggest limitation of cisplatin-based therapy is the development of cisplatin resistance. Cancer cells overcome the vast DNA damage caused by the drug in a variety of ways such as detoxication and extracellular transport of the drug, enhanced repair mechanisms, omitting apoptosis and epigenetic alterations. Chemotherapy resistance is an issue that so far cannot be dealt with. Nevertheless, better understanding of the molecular pathways behind cisplatin resistance brings hope for better therapy outcomes in lung cancer patients.en
dc.language.isoen
dc.publisherWydawnictwo Uniwersytetu Łódzkiegopl
dc.relation.ispartofseriesActa Universitatis Lodziensis. Folia Biologica et Oecologicaen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectnon-small-cell lung canceren
dc.subjectcisplatinen
dc.subjectcisplatin resistanceen
dc.titleA brief dive into the phenomenon of cisplatin resistance in non-small-cell lung canceren
dc.typeArticle
dc.page.number37-41
dc.contributor.authorAffiliationUniversity of Lodz, Faculty of Biology and Environmental Protection, Department of General Biophysics, Pomorska 141/143, 90-236 Lodz, Polanden
dc.identifier.eissn2083-8484
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dc.contributor.authorEmailmaciej.sobczak@biol.uni.lodz.pl
dc.identifier.doi10.18778/1730-2366.16.12
dc.relation.volume17


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