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Infectious Agents as Stimuli of Trained Innate Immunity

dc.contributor.authorFol, Marek
dc.contributor.authorRusek, Paulina
dc.contributor.authorDruszczynska, Magdalena
dc.contributor.authorWala, Mateusz
dc.date.accessioned2021-09-17T08:14:39Z
dc.date.available2021-09-17T08:14:39Z
dc.date.issued2018
dc.identifier.citationRusek, P.; Wala, M.; Druszczyńska, M.; Fol, M. Infectious Agents as Stimuli of Trained Innate Immunity. Int. J. Mol. Sci. 2018, 19, 456. https://doi.org/10.3390/ijms19020456pl_PL
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/11089/39084
dc.description.abstractThe discoveries made over the past few years have modified the current immunological paradigm. It turns out that innate immunity cells can mount some kind of immunological memory, similar to that observed in the acquired immunity and corresponding to the defense mechanisms of lower organisms, which increases their resistance to reinfection. This phenomenon is termed trained innate immunity. It is based on epigenetic changes in innate immune cells (monocytes/macrophages, NK cells) after their stimulation with various infectious or non-infectious agents. Many infectious stimuli, including bacterial or fungal cells and their components (LPS, β-glucan, chitin) as well as viruses or even parasites are considered potent inducers of innate immune memory. Epigenetic cell reprogramming occurring at the heart of the phenomenon may provide a useful basis for designing novel prophylactic and therapeutic strategies to prevent and protect against multiple diseases. In this article, we present the current state of art on trained innate immunity occurring as a result of infectious agent induction. Additionally, we discuss the mechanisms of cell reprogramming and the implications for immune response stimulation/manipulation.pl_PL
dc.language.isoenpl_PL
dc.publisherMDPIpl_PL
dc.relation.ispartofseriesInternational Journal of Molecular Sciences;19(2), 456
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectinnate immunity trainingpl_PL
dc.subjectepigenetic reprogrammingpl_PL
dc.subjectinnate immune memorypl_PL
dc.subjectbacille Calmette-Guérin (BCG)pl_PL
dc.subjectβ-glucanpl_PL
dc.subjectchitinpl_PL
dc.subjectlipopolysaccharide (LPS)pl_PL
dc.titleInfectious Agents as Stimuli of Trained Innate Immunitypl_PL
dc.typeArticlepl_PL
dc.page.number13pl_PL
dc.contributor.authorAffiliationDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha St. 12/16, 90-237 Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha St. 12/16, 90-237 Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha St. 12/16, 90-237 Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Plant Physiology and Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Banacha St. 12/16, 90-237 Lodz, Polandpl_PL
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dc.identifier.doihttps://doi.org/10.3390/ijms19020456
dc.disciplinenauki biologicznepl_PL


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