Endocannabinoid system and anticancer properties of cannabinoids

Śledziński, Paweł; Nowak, Agnieszka; Zeyland, Joanna; Słomski, Ryszard

dc.contributor.author	Śledziński, Paweł	en
dc.contributor.author	Nowak, Agnieszka	en
dc.contributor.author	Zeyland, Joanna	en
dc.contributor.author	Słomski, Ryszard	en
dc.date.accessioned	2017-03-07T07:40:16Z
dc.date.available	2017-03-07T07:40:16Z
dc.date.issued	2017-02-07	en
dc.identifier.issn	1730-2366	en
dc.identifier.uri	http://hdl.handle.net/11089/20772
dc.description.abstract	Cannabinoids impact human body by binding to cannabinoids receptors (CB1 and CB2). The two main phytocannabinoids are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC interacts with CB1 receptors occurring in central nervous system and is responsible for psychoactive properties of marijuana. CBD has low affinity to CB1 receptor, has no psychoactive characteristics and its medical applications can be wider. CB receptors are part of a complex machinery involved in regulation of many physiological processes – endocannabinoid system. Cannabinoids have found some applications in palliative medicine, but there are many reports concerning their anticancer affects. Agonists of CB1 receptors stimulate accumulation of ceramides in cancer cells, stress of endoplasmic reticulum (ER stress) and, in turn, apoptosis. Effects of cannabinoids showing low affinity to CB receptors is mediated probably by induction of reactive oxygen species production. Knowledge of antitumor activity of cannabinoids is still based only on preclinical studies and there is a necessity to conduct more experiments to assess the real potential of these compounds.	en
dc.publisher	Wydawnictwo Uniwersytetu Łódzkiego	en
dc.relation.ispartofseries	Folia Biologica et Oecologica;12	en
dc.rights	This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0	en
dc.subject	cannabinoids	en
dc.subject	cancer	en
dc.subject	tetrahydrocannabinol	en
dc.subject	THC	en
dc.subject	cannabidiol	en
dc.subject	CBD	en
dc.title	Endocannabinoid system and anticancer properties of cannabinoids	en
dc.page.number	11-25	en
dc.contributor.authorAffiliation	Śledziński, Paweł - 1. Poznań University of Life Sciences, Faculty of Biochemistry and Biotechnology, Dojazd 11, 60-632 Poznań	en
dc.contributor.authorAffiliation	Nowak, Agnieszka - 1. Poznań University of Life Sciences, Faculty of Biochemistry and Biotechnology, Dojazd 11, 60-632 Poznań	en
dc.contributor.authorAffiliation	Zeyland, Joanna - 1. Poznań University of Life Sciences, Faculty of Biochemistry and Biotechnology, Dojazd 11, 60-632 Poznań	en
dc.contributor.authorAffiliation	Słomski, Ryszard - 1. Poznań University of Life Sciences, Faculty of Biochemistry and Biotechnology, Dojazd 11, 60-632 Poznań	en
dc.contributor.authorAffiliation	Słomski, Ryszard - 2. Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań	en
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dc.contributor.authorEmail	Śledziński, Paweł - pawel717@gmail.com	en
dc.identifier.doi	10.1515/fobio-2016-0002	en

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