Znaczenie erytrocytów w aktywacji płytek krwi

Abstract

The blood platelet activation plays an important role in haemostasis. Mechanism of platelet activation is accompanied by intracellular signal transduction pathways that are responsible for different physiological responses of platelets: changes in platelet shape, release of their granule contents and platelet aggregation. Platelets circulate in vivo together with huge masses of erythrocytes and some leukocytes. Cell-cell interactions between platelets and neutrophils or platelets and erythrocytes can significantly alter platelet reactivity. In recent years demonstrated that erythrocytes may enhance platelet release reaction and eicosanoid synthesis. Role of erythrocytes in blood platelet activation are described and eicosanoid synthesis.