Zmiany aktywacji płytek krwi wywołane działaniem leku antynowotworowego - cisplatyny

Abstract

The effects of cisplatin and transplatin on the ADP (10 μM) - induced aggregation and secretion in vitro were studied. Platinum compounds had an inhibitory effect on ADP-induced platelet aggregation and secretion of adenine nucleotides and proteins from blood platelets. Cisplatin and transplatin also changed the metabolism of endogenous platelet arachidonate and thromboxne A2 synthesis in platelets stimulated by thrombin.