Ekspresja P-selektyny na powierzchni płytek krwi indukowana endotoksyną bakteryjną Proteus mirabilis
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Data
2001Autor
Saluk-Juszczak, Joanna
Nowak, Paweł
Golański, Jacek
Wachowicz, Barbara
Kaca, Wiesław
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P-selectin is stored in the a granules of blood platelets. Following platelet activation by
different agonists, P-selectin is expressed on the cell surface where it mediates adhesion
primarily to leucocytes.The aim of the study was to evaluate the direct effect of Proteus
mirabilis lipopolysaccharides on the P-selectin expression on the platelet surface measured by
cytometric method. The obtained results showed that LPS in vitro induced the expression of
P-selectin (CD62) on platelets. It indicates that endotoxin from Gram-negative bacteria can
activate blood platelets.