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Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids

dc.contributor.authorPlech, Tomasz
dc.contributor.authorKaproń, Barbara
dc.contributor.authorPaneth, Agata
dc.contributor.authorKosikowska, Urszula
dc.contributor.authorMalm, Anna
dc.contributor.authorStrzelczyk, Aleksandra
dc.contributor.authorStączek, Paweł
dc.contributor.authorŚwiątek, Łukasz
dc.contributor.authorRajtar, Barbara
dc.contributor.authorPolz-Dacewicz, Małgorzata
dc.date.accessioned2015-08-31T12:46:32Z
dc.date.available2015-08-31T12:46:32Z
dc.date.issued2015-04-09
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/11089/11603
dc.description.abstractWe have synthesized and examined the antibacterial activity, toxicity and affinity towards bacterial type II topoisomerases of a series of 1,2,4-triazole-ciprofloxacin hybrids. A number of these compounds displayed enhanced activity against Gram-positive and Gram-negative bacteria when compared to ciprofloxacin. The toxic concentrations of the obtained derivatives, evaluated on HEK-293 cells using MTT assay, were much higher than concentrations required to produce antibacterial effect. Finally, the results of enzymatic studies showed that the analyzed compounds demonstrated other preferences as regards primary and secondary molecular targets than ciprofloxacin.pl_PL
dc.description.sponsorshipThis research was supported by the Ministry of Science and Higher Education under Iuventus Plus grant No. IP2014 037473. Tomasz Plech is a recipient of the Fellowship for Young Researchers with Outstanding Scientific Achievements from the Medical University of Lublin (Lublin, Poland).pl_PL
dc.language.isoenpl_PL
dc.publisherMolecular Diversity Preservation International,pl_PL
dc.relation.ispartofseriesMolecules;2015
dc.rightsUznanie autorstwa 3.0 Polska*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/pl/*
dc.subjectfluoroquinolonespl_PL
dc.subjectgyrase DNApl_PL
dc.subjecttopoisomerase IVpl_PL
dc.subjecttopoisomerase inhibitorspl_PL
dc.subjectMTT assaypl_PL
dc.titleDetermination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybridspl_PL
dc.typeArticlepl_PL
dc.page.number6254-6272pl_PL
dc.contributor.authorAffiliationPlech Tomasz, Department of Organic Chemistry, Faculty of Pharmacy, Medical University Lublinpl_PL
dc.contributor.authorAffiliationKaproń Barbara, Department of Organic Chemistry, Faculty of Pharmacy, Medical University Lublinpl_PL
dc.contributor.authorAffiliationPaneth Agata, Department of Organic Chemistry, Faculty of Pharmacy, Medical University Lublinpl_PL
dc.contributor.authorAffiliationKosikowska Urszula, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Medical University Lublinpl_PL
dc.contributor.authorAffiliationMalm Anna, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Medical University Lublinpl_PL
dc.contributor.authorAffiliationStrzelczyk Aleksandra, Department of Genetics of Microorganisms, University of Lodzpl_PL
dc.contributor.authorAffiliationStączek Paweł, Department of Genetics of Microorganisms, University of Lodzpl_PL
dc.contributor.authorAffiliationŚwiątek Łukasz, Department of Virology, Faculty of Medicine, Medical University Lublinpl_PL
dc.contributor.authorAffiliationRajtar Barbara, Department of Virology, Faculty of Medicine, Medical University Lublinpl_PL
dc.contributor.authorAffiliationPolz-Dacewicz Małgorzata, Department of Virology, Faculty of Medicine, Medical University Lublinpl_PL
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dc.contributor.authorEmailola.strzelczyk@wp.plpl_PL
dc.contributor.authorEmailpstaczek@biol.uni.lodz.plpl_PL
dc.identifier.doidoi:10.3390/molecules20046254
dc.relation.volume20pl_PL


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