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The artificial oxygen carrier erythrocruorin—characteristics and potential significance in medicine

dc.contributor.authorKruczkowska, Weronika
dc.contributor.authorKciuk, Mateusz
dc.contributor.authorPasieka, Zbigniew
dc.contributor.authorKłosiński, Karol
dc.contributor.authorPłuciennik, Elżbieta
dc.contributor.authorElmer, Jacob
dc.contributor.authorWaszczykowska, Klaudia
dc.contributor.authorKołat, Damian
dc.contributor.authorKałuzińska-Kołat, Żaneta
dc.date.accessioned2023-08-10T12:16:55Z
dc.date.available2023-08-10T12:16:55Z
dc.date.issued2023
dc.identifier.citationKruczkowska Weronika, Kciuk Mateusz, Pasieka Zbigniew, Kłosiński Karol, Płuciennik Elżbieta, Elmer Jacob, Waszczykowska Klaudia, Kołat Damian, Kałuzińska-Kołat Żaneta: The artificial oxygen carrier erythrocruorin— characteristics and potential significance in medicine, Journal of Molecular Medicine-Jmm, vol. 101, nr 8, 2023, s. 961-972, DOI:10.1007/s00109-023- 02350-3pl_PL
dc.identifier.issn0946-2716
dc.identifier.urihttp://hdl.handle.net/11089/47769
dc.description.abstractThe diminishing supply and increasing costs of donated blood have motivated research into novel hemoglobin-based oxygen carriers (HBOCs) that can serve as red blood cell (RBC) substitutes. HBOCs are versatile agents that can be used in the treatment of hemorrhagic shock. However, many of the RBC substitutes that are based on mammalian hemoglobins have presented key limitations such as instability and toxicity. In contrast, erythrocruorins (Ecs) are other types of HBOCs that may not suffer these disadvantages. Ecs are giant metalloproteins found in annelids, crustaceans, and some other invertebrates. Thus far, the Ecs of Lumbricus terrestris (LtEc) and Arenicola marina (AmEc) are the most thoroughly studied. Based on data from preclinical transfusion studies, it was found that these compounds not only efficiently transport oxygen and have anti-inflammatory properties, but also can be modified to further increase their effectiveness. This literature review focuses on the structure, properties, and application of Ecs, as well as their advantages over other HBOCs. Development of methods for both the stabilization and purification of erythrocruorin could confer to enhanced access to artificial blood resources.pl_PL
dc.language.isoenpl_PL
dc.publisherSpringer Naturepl_PL
dc.relation.ispartofseriesJournal of Molecular Medicine;101
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectErythrocruorinpl_PL
dc.subjectHemoglobinpl_PL
dc.subjectArtificial oxygen carrierspl_PL
dc.subjectRed blood cell substitutespl_PL
dc.titleThe artificial oxygen carrier erythrocruorin—characteristics and potential significance in medicinepl_PL
dc.typeArticlepl_PL
dc.page.number961-972pl_PL
dc.contributor.authorAffiliationFaculty of Biomedical Sciences, Medical University of Lodz, Zeligowskiego 7/9, 90-752, Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Molecular Biotechnology and Genetics, University of Lodz, Banacha 12/16, 90-237, Lodz, Poland; Doctoral School of Exact and Natural Sciences, University of Lodz, Banacha 12/16, 90-237, Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Experimental Surgery, Medical University of Lodz, Narutowicza 60, 90-136, Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Experimental Surgery, Medical University of Lodz, Narutowicza 60, 90-136, Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Functional Genomics, Medical University of Lodz, Zeligowskiego 7/9, 90-752, Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Chemical and Biological Engineering, Villanova University, Villanova, PA, USApl_PL
dc.contributor.authorAffiliationDepartment of Functional Genomics, Medical University of Lodz, Zeligowskiego 7/9, 90-752, Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Experimental Surgery, Medical University of Lodz, Narutowicza 60, 90-136, Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Experimental Surgery, Medical University of Lodz, Narutowicza 60, 90-136, Lodz, Polandpl_PL
dc.identifier.eisbn1432-1440
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dc.identifier.doi10.1007/s00109-023-02350-3
dc.disciplinenauki medycznepl_PL
dc.disciplinenauki biologicznepl_PL


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