Application of diethyl ethynylphosphonate to the synthesis of 3‐phosphonylated β‐lactams via the Kinugasa reaction
Abstract
The easily available diethyl ethynylphosphonate reacts with diverse aldonitrones under Kinugasa reaction
conditions at room temperature, providing 3‐phosphonylated β‐lactams in good yields. In all cases, the
reaction led to the trans‐isomer exclusively. The trans‐configuration was assigned based on 1H‐NMR spectroscopic analysis.
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