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dc.contributor.authorSzczupak, Łukasz
dc.contributor.authorHikisz, Paweł
dc.contributor.authorKoceva-Chyla, Aneta
dc.contributor.authorKowalski, Konrad
dc.contributor.authorGuśpiel, Adam
dc.contributor.authorSolecka, Jolanta
dc.contributor.authorTherrien, Bruno
dc.contributor.authorOtt, Ingo
dc.contributor.authorOehninger, Luciano
dc.identifier.citationHikisz, P.; Szczupak, Ł.; Koceva-Chyła, A.; Guśpiel, A.; Oehninger, L.; Ott, I.; Therrien, B.; Solecka, J.; Kowalski, K. Anticancer and Antibacterial Activity Studies of Gold(I)-Alkynyl Chromones. Molecules 2015, 20, 19699-19718.
dc.description.abstractThree gold(I) complexes of alkynyl chromones were synthesized and characterized. The single-crystal X-ray structure analysis of a dinuclear compound and of a flavone derivative exhibit a typical d10 gold(I)-alkynyl linear arrangement. All complexes were evaluated as anticancer and antibacterial agents against four human cancer cell lines and four pathogenic bacterial strains. All compounds show antiproliferative activity at lower micromolar range concentrations. Complex 4 showed a broad activity profile, being more active than the reference drug auranofin against HepG2, MCF-7 and CCRF-CEM cancer cells. The cellular uptake into MCF-7 cells of the investigated complexes was measured by atomic absorption spectroscopy (AAS). These measurements showed a positive correlation between an increased cellular gold content and the incubation time of the complexes. Unexpectedly an opposite effect was observed for the most active compound. Biological assays revealed various molecular mechanisms for these compounds, comprising: (i) thioredoxin reductase (TrxR) inhibition, (ii) caspases-9 and -3 activation; (iii) DNA damaging activity and (iv) cell cycle disturbance. The gold(I) complexes were also bactericidal against Gram-positive methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) bacterial strains, while showing no activity against the Gram-negative Escherichia coli bacterial strain.pl_PL
dc.description.sponsorshipSupplementary Materials: Supplementary materials can be accessed at: 20/11/19647/s1. Acknowledgments: K.K. thanks the National Science Centre in Cracow, Poland (Grant no. DEC-2011/03/B/ ST5/01015) for financial support. Author Contributions: Syntheses: Ł.S., K.K. Biology: P.H., A.K.-C. Microbiology: A.G., J.S., Atomic Absorption Spectroscopy Measurements: L.O., I.O. Research concept: K.K. X-ray structure: B.T. Writing and discussions: K.K., B.T., I.O., J.S., A.K.-C.pl_PL
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.subjectanticancer activitypl_PL
dc.subjectgold(I) complexespl_PL
dc.subjectantibacterial activitypl_PL
dc.titleAnticancer and Antibacterial Activity Studies of Gold(I)-Alkynyl Chromonespl_PL
dc.contributor.authorAffiliationDepartment of Organic Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, Łódź PL-91403, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Thermobiology, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, Łódź PL-90236, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Thermobiology, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, Łódź PL-90236, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Organic Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, Łódź PL-91403, Polandpl_PL
dc.contributor.authorAffiliationLaboratory of Biologically Active Compounds, National Institute of Public Health-National Institute of Hygiene, Chocimska 24, Warsaw PL-00791, Polandpl_PL
dc.contributor.authorAffiliationLaboratory of Biologically Active Compounds, National Institute of Public Health-National Institute of Hygiene, Chocimska 24, Warsaw PL-00791, Polandpl_PL
dc.contributor.authorAffiliationInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, Braunschweig D-38106, Germanypl_PL
dc.contributor.authorAffiliationInstitute of Chemistry, Faculty of Science, University of Neuchatel, Avenue de Bellevaux 51, Neuchatel CH-2000, Switzerlandpl_PL
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Uznanie autorstwa 4.0 Międzynarodowe
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