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Calorimetric and spectroscopic investigations of interactions between cucurbituril Q7 and gemcitabine in aqueous solutions

dc.contributor.authorUrbaniak, Paweł
dc.contributor.authorBuczkowski, Adam
dc.contributor.authorStepniak, Artur
dc.contributor.authorPalecz, Bartłomiej
dc.date.accessioned2021-09-09T09:36:18Z
dc.date.available2021-09-09T09:36:18Z
dc.date.issued2018
dc.identifier.citationBuczkowski, A., Stepniak, A., Urbaniak, P. et al. Calorimetric and spectroscopic investigations of interactions between cucurbituril Q7 and gemcitabine in aqueous solutions. J Therm Anal Calorim 134, 595–607 (2018). https://doi.org/10.1007/s10973-018-7295-7pl_PL
dc.identifier.issn1388-6150
dc.identifier.urihttp://hdl.handle.net/11089/39011
dc.description.abstractStudies on the interactions between cucurbituril Q7 and gemcitabine (Gem) hydrochloride in water were carried out using isothermal titration calorimetry (ITC) and electrospray ionization–mass spectrometry (ESI-MS). According to ITC and ESI-MS, the formation of this complex occurs in both the solution containing excess gemcitabine and the solution containing excess cucurbituril Q7. ITC results confirm the formation of a thermodynamically stable supramolecular complex with stoichiometry 1:1. The inclusion mechanism of Gem inside the cucurbituril macromolecule is spontaneous (ΔG<0). This process is exothermic (ΔH<0) and is characterized by the loss of entropy (ΔS<0).pl_PL
dc.description.sponsorshipThe study was financed from the Grant for Development of Young Researchers from the Faculty of Chemistry, University of Lodz, 2017.pl_PL
dc.language.isoenpl_PL
dc.publisherSpringer Nature [Co-publication with Akadémiai Kiadó, Budapest, Hungary]pl_PL
dc.relation.ispartofseriesJournal of Thermal Analysis and Calorimetry;134
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCucurbituril Q7pl_PL
dc.subjectCB[7pl_PL
dc.subjectGemcitabine hydrochloridepl_PL
dc.subjectIsothermal titration calorimetrypl_PL
dc.subjectProtonation constant of gemcitabinepl_PL
dc.titleCalorimetric and spectroscopic investigations of interactions between cucurbituril Q7 and gemcitabine in aqueous solutionspl_PL
dc.typeArticlepl_PL
dc.page.number595–607pl_PL
dc.contributor.authorAffiliationDepartment of Inorganic and Analytical Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403, Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Biophysical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 165, 90-236, Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Biophysical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 165, 90-236, Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Biophysical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 165, 90-236, Lodz, Polandpl_PL
dc.identifier.eissn1588-2926
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dc.identifier.doi10.1007/s10973-018-7295-7
dc.disciplinenauki chemicznepl_PL


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