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dc.contributor.authorUrbaniak, Paweł
dc.contributor.authorBuczkowski, Adam
dc.contributor.authorStepniak, Artur
dc.contributor.authorPalecz, Bartłomiej
dc.identifier.citationBuczkowski, A., Stepniak, A., Urbaniak, P. et al. Calorimetric and spectroscopic investigations of interactions between cucurbituril Q7 and gemcitabine in aqueous solutions. J Therm Anal Calorim 134, 595–607 (2018).
dc.description.abstractStudies on the interactions between cucurbituril Q7 and gemcitabine (Gem) hydrochloride in water were carried out using isothermal titration calorimetry (ITC) and electrospray ionization–mass spectrometry (ESI-MS). According to ITC and ESI-MS, the formation of this complex occurs in both the solution containing excess gemcitabine and the solution containing excess cucurbituril Q7. ITC results confirm the formation of a thermodynamically stable supramolecular complex with stoichiometry 1:1. The inclusion mechanism of Gem inside the cucurbituril macromolecule is spontaneous (ΔG<0). This process is exothermic (ΔH<0) and is characterized by the loss of entropy (ΔS<0).pl_PL
dc.description.sponsorshipThe study was financed from the Grant for Development of Young Researchers from the Faculty of Chemistry, University of Lodz, 2017.pl_PL
dc.publisherSpringer Nature [Co-publication with Akadémiai Kiadó, Budapest, Hungary]pl_PL
dc.relation.ispartofseriesJournal of Thermal Analysis and Calorimetry;134
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.subjectCucurbituril Q7pl_PL
dc.subjectGemcitabine hydrochloridepl_PL
dc.subjectIsothermal titration calorimetrypl_PL
dc.subjectProtonation constant of gemcitabinepl_PL
dc.titleCalorimetric and spectroscopic investigations of interactions between cucurbituril Q7 and gemcitabine in aqueous solutionspl_PL
dc.contributor.authorAffiliationDepartment of Inorganic and Analytical Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403, Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Biophysical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 165, 90-236, Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Biophysical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 165, 90-236, Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Biophysical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 165, 90-236, Lodz, Polandpl_PL
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Uznanie autorstwa 4.0 Międzynarodowe
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