Zmiany poziomu glutationu i aktywności transferazy glutationowej w płytkach krwi indukowane związkami selenu
Oglądaj/ Otwórz
Data
1997Autor
Zbikowska, Halina
Krajewski, Tadeusz
Wachowicz, Barbara
Metadata
Pokaż pełny rekordStreszczenie
The effects of inorganic selenocompounds (sodium selenite and selenate) on the level of
reduced glutathione, free sulfhydryl groups of proteins and the activity of S-glutathione
transferase (GST) in pig blood platelets were studied. It was shown that selenite, contrary to
selenate reduced the amounts of both GSH and -SH of platelet proteins. The concentration
of GSH after one-hour treatment of platelets with a high dose of selenite (10-4 M) was
reduced by 50%. A decrease in protein thiols was also significant. We observed that the
activity of platelet GST was inhibited after incubation of these cells with a toxic dose of
selenite but not selenate.